YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25 -: I.: Taxonomy, fermentation, isolation and characterization

被引：15

作者：

Bahn, YS

Park, JM

Bai, DH

Takase, S

Yu, JH

机构：

[1] Yonsei Univ, Dept Food & Biotechnol, Sudaemun Ku, Seoul 120749, South Korea

[2] Yonsei Univ, Bioprod Res Ctr, Sudaemun Ku, Seoul 120749, South Korea

[3] Dankook Univ, Dept Food Engn, Chunan 330714, South Korea

[4] Fujisawa Pharmaceut Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 30026, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 10期

关键词：

D O I：

10.7164/antibiotics.51.902

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

YUA001 is a novel aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25 isolated from soil. YUA001 was purified from the supernatant of culture broth by successive silica gel column chromatography, Sephadex LH20-100 gel column chromatography, and HPLC. From instrumental analysis, molecular formula of YUA001 is C13H19NO2 and its molecular weight is 221. It exhibits potent aldose reductase inhibition activity and has no antimicrobial activity against some Gram-positive or Gram-negative bacteria, fungi and yeast.

引用

页码：902 / 907

页数：6

共 11 条

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