The discovery of anthranilic acid-based MMP inhibitors.: Part 2:: SAR of the 5-position and P11 groups

被引：74

作者：

Levin, JI

Chen, J

Du, M

Hogan, M

Kincaid, S

Nelson, FC

Venkatesan, AM

Wehr, T

Zask, A

DiJoseph, J

Killar, LM

Skala, S

Sung, A

Sharr, M

Roth, C

Jin, G

Cowling, R

Mohler, KM

Black, RA

March, CJ

Skotnicki, JS

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Princeton, NJ 08543 USA

[3] Immunex Res & Dev Corp, Seattle, WA 98101 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(01)00419-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of anthranilic acid-based inhibitors of MMP-1. MMP-9, MMP-13. and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 inhibitor 4p. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2189 / 2192

页数：4

共 21 条

[1] A NOVEL IN-VIVO MODEL FOR THE STUDY OF CARTILAGE DEGRADATION [J].