Therapeutic potential of bone morphogenetic proteins

被引:10
作者
Azari, K [1 ]
Doll, BA [1 ]
Sfeir, C [1 ]
Mu, Y [1 ]
Hollinger, JO [1 ]
机构
[1] Carnegie Mellon Univ, Bone Tissue Engn Ctr, Pittsburgh, PA 15213 USA
关键词
adipose; bone; bone morphogenetic proteins; kidney; liver; nervous system; therapy; tissue engineering;
D O I
10.1517/13543784.10.9.1677
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recently, there has been substantial progress in the area of bone morphogenetic protein (BMP) research. This review serves as an up-to-date summary of the history of BMPs, the mechanisms of BMP signalling and the role of BMPs in adipose, kidney, liver, bone and nervous system. The potential of BMPs as therapeutic agents will also be discussed.
引用
收藏
页码:1677 / 1686
页数:10
相关论文
共 103 条
[1]  
Almanzar MM, 1998, J AM SOC NEPHROL, V9, P1456
[2]  
Arkell R, 1997, DEVELOPMENT, V124, P1
[3]   Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells [J].
Asahina, I ;
Sampath, TK ;
Hauschka, PV .
EXPERIMENTAL CELL RESEARCH, 1996, 222 (01) :38-47
[4]   From receptor to nucleus: the Smad pathway [J].
Baker, JC ;
Harland, RM .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) :467-473
[5]  
Baltzer AWA, 2000, CLIN ORTHOP RELAT R, pS120
[6]   MAMMALIAN SUBTILISINS - THE LONG-SOUGHT DIBASIC PROCESSING ENDOPROTEASES [J].
BARR, PJ .
CELL, 1991, 66 (01) :1-3
[7]   Biology of lumbar spine fusion and use of bone graft substitutes: Present, future, and next generation [J].
Boden, SD .
TISSUE ENGINEERING, 2000, 6 (04) :383-399
[8]  
Boden SD, 2000, CLIN ORTHOP RELAT R, pS225
[9]  
Boyne P J, 1997, Int J Periodontics Restorative Dent, V17, P11
[10]  
Burt David W., 1994, Progress in Growth Factor Research, V5, P99