Requirement of type III TGF-β receptor for endocardial cell transformation in the heart

被引：305

作者：

Brown, CB

Boyer, AS

Runyan, RB

Barnett, JV

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med & Pharmacol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

[3] Univ Arizona, Univ Heart Ctr, Dept Cell Biol & Anat, Tucson, AZ 85724 USA

来源：

SCIENCE | 1999年 / 283卷 / 5410期

关键词：

D O I：

10.1126/science.283.5410.2080

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor-beta (TGF-beta) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) Lacks a recognizable signaling domain and has no clearly defined role in TGF-beta signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-beta 2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling.

引用

页码：2080 / 2082

页数：3

共 31 条

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