Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

被引：72

作者：

Bian, Yongqian ^{[1
]}

Wang, Li ^{[2
]}

Lu, Huanyu ^{[2
]}

Yang, Guodong ^{[2
]}

Zhang, Zhang ^{[1
]}

Fu, Haiyan ^{[2
]}

Lu, Xiaozhao ^{[2
]}

Wei, Mengying ^{[2
]}

Sun, Jianyong ^{[1
]}

Zhao, Qingchuan ^{[1
]}

Dong, Guanglong ^{[1
,3
]}

Lu, Zifan ^{[2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Peoples R China

[3] Gen Hosp PLA, Dept Gen Surg, Beijing 100853, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 422卷 / 01期

关键词：

Gastric cancer; RNA binding protein QKI; Methylation; Prognosis; RNA-BINDING PROTEIN; CELL-CYCLE; QUAKING; DIFFERENTIATION; CARCINOMA; P27(KIP1); DELETIONS; REGIONS; RISK; 6Q;

D O I：

10.1016/j.bbrc.2012.04.138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：187 / 193

页数：7

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