In Vivo Diffusion Tensor Imaging of Chronic Spinal Cord Compression in Rat Model

被引：16

作者：

Cheung, Matthew M. ^{[1
,2
]}

Li, Darrell T. H. ^{[3
]}

Hui, Edward S. ^{[1
,2
]}

Fan, Shujuan

Ding, Abby Y. ^{[1
,2
]}

Hu, Yong ^{[3
]}

Wu, Ed X. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Pokfulam, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Elect Elect Engn, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Traumat & Orthopaed, Hong Kong, Hong Kong, Peoples R China

来源：

2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 | 2009年

关键词：

Cervical myelopathy; MRI; DTI; spinal cord compression; axial diffusivity; radial diffusivity; CERVICAL MYELOPATHY; INJURY; MRI; DAMAGE; WATER;

D O I：

10.1109/IEMBS.2009.5333389

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Chronic spinal cord compression induced cervical myelopathy is a comon cause of spinal cord dysfunction. The exact mechanisms of underlying progressive cell death remain to be elucidated. In this study, in vivo diffusion tensor imaging (DTI) has been applied to investigate the microstructural changes of white matter (WM) in this neurodegenerative disease. Compared with conventional MRI techniques, DTI is believed to be more specific to pathological changes. Radial diffusivity (lambda perpendicular to) is higher in the ipilesional region, suggesting demyelination or axonal degradation may occur after prolonged compression. Near the epicenter of lesion, axial diffusivity (lambda(//)) is lower. Also, caudal-rostral asymmetry has been observed in lambda(//). Feasibility of using DTI to detect microstructural changes in chronic disease has been demonstrated.

引用

页码：2715 / 2718

页数：4

共 24 条

[1]

EXPERIMENTAL CHRONIC COMPRESSIVE CERVICAL MYELOPATHY [J].

ALMEFTY, O ;

HARKEY, HL ;

MARAWI, I ;

HAINES, DE ;

PEELER, DF ;

WILNER, HI ;

SMITH, RR ;

HOLADAY, HR ;

HAINING, JL ;

RUSSELL, WF ;

HARRISON, B ;

MIDDLETON, TH .

JOURNAL OF NEUROSURGERY, 1993, 79 (04) :550-561

[2]

Baptiste Darryl C, 2006, Spine J, V6, p190S, DOI 10.1016/j.spinee.2006.04.024

[3]

The basis of anisotropic water diffusion in the nervous system - a technical review [J].

Beaulieu, C .

NMR IN BIOMEDICINE, 2002, 15 (7-8) :435-455

[4]

Toward accurate diagnosis of white matter pathology using diffusion tensor imaging [J].

Budde, Matthew D. ;

Kim, Joong Hee ;

Liang, Hsiao-Fang ;

Schmidt, Robert E. ;

Russell, John H. ;

Cross, Anne H. ;

Song, Sheng-Kwei .

MAGNETIC RESONANCE IN MEDICINE, 2007, 57 (04) :688-695

[5]

Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study [J].

Cheung, Matthew M. ;

Hui, Edward S. ;

Chan, Kevin C. ;

Helpern, Joseph A. ;

Qi, Liqun ;

Wu, Ed X. .

NEUROIMAGE, 2009, 45 (02) :386-392

[6]

Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients [J].

Concha, Luis ;

Gross, Donald W. ;

Wheatley, B. Matt ;

Beaulieu, Christian .

NEUROIMAGE, 2006, 32 (03) :1090-1099

[7]

In vivo serial diffusion tensor imaging of experimental spinal cord injury [J].

Deo, AA ;

Grill, RJ ;

Hasan, KM ;

Narayana, PA .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 83 (05) :801-810

[8]

In vivo diffusion tensor imaging of the rat spinal cord at 9.4T [J].

Ellingson, Benjamin M. ;

Kurpad, Shekar N. ;

Li, Shi-Jiang ;

Schmit, Brian D. .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2008, 27 (03) :634-642

[9]

Ex Vivo Diffusion Tensor Imaging and Quantitative Tractography of the Rat Spinal Cord During Long-term Recovery From Moderate Spinal Contusion [J].

Ellingson, Benjamin M. ;

Kurpad, Shekar N. ;

Schmit, Brian D. .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2008, 28 (05) :1068-1079

[10]

Falconer JC, 1996, J NEUROCHEM, V66, P717

← 1 2 3 →