A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

被引：160

作者：

Annoura, H

Fukunaga, A

Uesugi, M

Tatsuoka, T

Horikawa, Y

机构：

[1] Suntory Inst. for Biomed. Research, Mishima-gun, Osaka 618, 1-1-1, Wakayama-dai, Shimamoto-cho

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00104-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7-(Hydroxyimino)cyclopropa[b] chromen-1a-carboxylates (4a-c), highly potent antagonists for a phospholipase C-linked metabotropic glutamate receptor, mGluR1, were synthesized through cyclopropanation onto 4-oxo-4H-1-benzopyran-2-carboxylates (5a-c) utilizing dimethyloxosulfonium methylid followed by treatment with hydroxylamine. Copyright (C) 1996 Elsevier Science Ltd

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页码：763 / 766

页数：4

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