Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea

被引：39

作者：

Jiang, Z

Boyd, KG

Mearns-Spragg, A

Adams, DR

Wright, PC

Burgess, JG

机构：

[1] Heriot Watt Univ, Dept Biol Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[3] Heriot Watt Univ, Dept Mech & Chem Engn, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

NATURAL PRODUCT LETTERS | 2000年 / 14卷 / 06期

关键词：

cyclo-(L-prolyl-L-glycine); cyclo-(L-phenylalanyl-4R-hydroxy-L-proline); 2,4-dibromo-6-chlorophenol; Pseudoalteromonas luteoviolacea; antibiotic;

D O I：

10.1080/10575630008043781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.

引用

页码：435 / 440

页数：6

共 19 条

[1] NOVEL SPONGE-DERIVED AMINO-ACIDS .5. STRUCTURES, STEREOCHEMISTRY, AND SYNTHESIS OF SEVERAL NEW HETEROCYCLES [J].