Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment

被引:41
作者
Forlenza, Orestes V. [1 ,2 ,3 ]
Diniz, Breno S. [2 ,3 ]
Talib, Leda L. [2 ,3 ]
Radanovic, Marcia [2 ,3 ]
Yassuda, Monica S. [2 ,3 ,4 ]
Ojopi, Elida B. [2 ,3 ]
Gattaz, Wagner F. [2 ,3 ]
机构
[1] Univ Sao Paulo, Lab Neurociencias LIM 27, Dept Psiquiatria, Hosp Clin,Fac Med,Sch Med, BR-05403010 Sao Paulo, Brazil
[2] Univ Sao Paulo, Psychogeriatr Clin, BR-05403010 Sao Paulo, Brazil
[3] Univ Sao Paulo, Lab Neurosci LIM 27, Inst Psychiat, Sch Med, BR-05403010 Sao Paulo, Brazil
[4] Univ Sao Paulo, Gerontol Sch Arts Sci & Humanities EACH, BR-05403010 Sao Paulo, Brazil
关键词
Alzheimer s disease; Cognition disorders; Critical pathways; Biological indicators; Neurobehavioral manifestations; CSF BIOMARKERS; OLDER-ADULTS; PROGRESSION; DIAGNOSIS; CONVERSION; DEMENTIA; METAANALYSIS; PERFORMANCE; DISORDER; CRITERIA;
D O I
10.1590/S1516-44462010005000002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective To identify predictors of the progression from pre-dementia stages of cognitive impairment in Alzheimer s disease is relevant to clinical management and to substantiate the decision of prescribing antidementia drugs Method Longitudinal study of a cohort of elderly adults with amnestic mild cognitive impairment and healthy controls carried out to estimate the risk and characterize predictors of the progression to Alzheimer s disease Results Patients with amnestic mild cognitive impairment had a higher risk to develop Alzheimer s disease during follow up (odds ratio = 4 5 CI95% [1 3 13 6] p = 0 010) At baseline older age lower scores on memory tests and presence of the APOE*4 allele predicted the progression from amnestic mild cognitive impairment to Alzheimer s disease In a sub sample of amnestic mild cognitive impairment patients those who progressed to Alzheimer s disease had lower cerebrospinal fluid concentrations of amyloid beta peptide (A beta(42) p = 0 020) and higher concentrations of total TAU (p = 0 030) and phosphorylated TAU (p = 0 010) as compared to non-converters Discussion This is the first Brazilian study to report cerebrospinal fluid biomarkers in the prediction of the conversion from MCI to Alzheimer s disease Our data are in accordance with those reported in other settings The measurement of cerebrospinal fluid total TAU phospho TAU and A beta(42) may help identify patients with mild cognitive impairment at higher risk for developing Alzheimer s disease
引用
收藏
页码:216 / 222
页数:7
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