Mitochondria and apoptosis

被引：8283

作者：

Green, DR

Reed, JC

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

[2] Burnham Inst, La Jolla, CA 92037 USA

来源：

SCIENCE | 1998年 / 281卷 / 5381期

关键词：

D O I：

10.1126/science.281.5381.1309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

引用

收藏

页码：1309 / 1312

页数：4

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