Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

被引：471

作者：

Eisele, Yvonne S. ^{[1
,2
]}

Obermueller, Ulrike ^{[1
,2
]}

Heilbronner, Goetz ^{[1
,2
,3
]}

Baumann, Frank ^{[1
,2
]}

Kaeser, Stephan A. ^{[1
,2
]}

Wolburg, Hartwig ^{[4
]}

Walker, Lary C. ^{[5
,6
]}

Staufenbiel, Matthias ^{[7
]}

Heikenwalder, Mathias ^{[8
]}

Jucker, Mathias ^{[1
,2
]}

机构：

[1] Univ Tubingen, Dept Cellular Neurol, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[2] DZNE German Ctr Neurodegenerat Dis, D-72076 Tubingen, Germany

[3] Univ Tubingen, Grad Sch Cellular & Mol Neurosci, D-72074 Tubingen, Germany

[4] Univ Tubingen, Dept Pathol, D-72076 Tubingen, Germany

[5] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

[6] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

[7] Novartis Inst Biomed Res, CH-4056 Basel, Switzerland

[8] Univ Zurich Hosp, Dept Pathol, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

SCIENCE | 2010年 / 330卷 / 6006期

关键词：

ALZHEIMER-DISEASE; PATHOGENESIS; DEPOSITION; PRIONS;

D O I：

10.1126/science.1194516

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intracerebral injection of beta-amyloid-containing brain extracts can induce cerebral beta-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with beta-amyloid-rich extracts induced beta-amyloidosis in the brains of beta-amyloid precursor protein transgenic mice after prolonged incubation times.

引用

页码：980 / 982

页数：3

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