Tourette's syndrome and deep brain stimulation

被引：230

作者：

Houeto, JL

Karachi, C

Mallet, L

Pillon, B

Yelnik, J

Mesnage, V

Welter, ML

Navarro, S

Pelissolo, A

Damier, P

Pidoux, B

Dormont, D

Cornu, P

Agid, Y

机构：

[1] Hop La Pitie Salpetriere, Ctr Invest Clin, INSERM, U289,IFR 70, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, EPI 007, INSERM, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, CNRS, UMR7593, F-75013 Paris, France

[4] Hop La Pitie Salpetriere, Federat Neurophysiol Clin, F-75013 Paris, France

[5] Hop La Pitie Salpetriere, Serv Neuroradiol, F-75013 Paris, France

[6] Hop La Pitie Salpetriere, Serv Neurochirurg, F-75013 Paris, France

[7] Hop Laennec, Serv Neurol, Nantes, France

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2005年 / 76卷 / 07期

关键词：

D O I：

10.1136/jnnp.2004.043273

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this prospective double blind randomised "N of 1'' study, a patient with a severe form of Tourette's syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette's syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder.

引用

页码：992 / 995

页数：4

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