The ageing mitochondrial genome

被引：61

作者：

Krishnan, Kim J. ^{[1
,2
]}

Greaves, Laura C. ^{[1
,2
]}

Reeve, Amy K. ^{[1
,2
]}

Turnbull, Doug ^{[1
,2
]}

机构：

[1] Univ Newcastle, Sch Med, Sch Neurol Neurobiol & Psychiat, Mitochondrial Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Newcastle, Sch Med, Inst Ageing & Hlth, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NUCLEIC ACIDS RESEARCH | 2007年 / 35卷 / 22期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1093/nar/gkm635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process.

引用

收藏

页码：7399 / 7405

页数：7

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