Chromatin regulation during C. elegans germline development

被引:14
作者
Shin, TH [1 ]
Mello, CC
机构
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
[3] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
[4] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
关键词
D O I
10.1016/S0959-437X(03)00109-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Recent studies in Caenorhabditis elegans implicate PcG- and NuRD-like chromatin regulators in the establishment and maintenance of germline-soma distinctions. Somatic cells appear to utilize NuRD-related nucleosome-remodeling factors to overwrite germline-specific chromatin states that are specified through PcG-like activities. The germline, in turn, may rely on an asymmetrically inherited inhibitor to prevent chromatin reorganization that would otherwise erase pluripotency.
引用
收藏
页码:455 / 462
页数:8
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