Exercise manages fatigue during breast cancer treatment: A randomized controlled trial

被引:268
作者
Mock, V
Frangakis, C
Davidson, NE
Ropka, ME
Pickett, M
Poniatowski, B
Stewart, KJ
Cameron, L
Zawacki, K
Podewils, LJ
Cohen, G
McCorkle, R
机构
[1] Johns Hopkins Univ Hosp, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD 21218 USA
[5] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA
[6] Univ Virginia, Sch Nursing, Charlottesville, VA 22903 USA
[7] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA
[8] Greater Baltimore Med Ctr, Baltimore, MD USA
[9] Yale Univ, Sch Nursing, New Haven, CT 06536 USA
关键词
D O I
10.1002/pon.863
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Fatigue is the most prevalent and debilitating symptom experienced by breast cancer patients receiving adjuvant chemotherapy or radiation therapy and few evidence-based treatments are available to manage this distressing side-effect. The purpose of this multi-institutional randomized controlled trial was to determine the effects of exercise on fatigue levels during treatment for breast cancer. Sedentary women (N= 119) with Stage 0-III breast cancer receiving outpatient adjuvant chemotherapy or radiation therapy were randomized to a home-based moderate-intensity walking exercise program or to usual care for the duration of their cancer treatment. Of participants randomized to exercise, 72% adhered to the exercise prescription; 61% of the usual care group adhered. The intention-to-treat analysis revealed no group differences in part because of a dilution of treatment effect as 39% of the usual care group exercised and 28% of the exercise group did not. When exercise participation was considered using the data analysis method of instrumental variables with principal stratification, a clinically important and statistically significant (p = 0.03) effect of exercise on pretest-to-posttest change in fatigue levels was demonstrated. Adherence to a home-based moderate-intensity walking exercise program may effectively mitigate the high levels of fatigue prevalent during cancer treatment. Copyright (c) 2004 John Wiley & Sons, Ltd.
引用
收藏
页码:464 / 477
页数:14
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