Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure

被引：76

作者：

Ogawa, S

Emi, M

Shiraki, M

Hosoi, T

Ouchi, Y

Inoue, S

机构：

[1] Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Tokyo, Japan

[3] Res Inst & Practice Involut Dis, Nagano, Japan

[4] Tokyo Metropolitan Geriatr Hosp, Tokyo 173, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 06期

关键词：

ESR2; polymorphism; systemic hypertension; microsatellite marker; allelic association;

D O I：

10.1007/s100380070002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated the association bi tween a dinucleotide (cytosine-adenine; CA) repeat polymorphism located in the flanking region of the human estrogen receptor beta (ESR2) gene and systemic blood pressure in 187 healthy postmenopausal Japanese women. The genotype was classified as "A" through "O" according to the number of these repeats from 18 to 32. When we separated the subjects into two groups - bearing at least one "I" allele (26 CA repeats) and those who did not - we found that the former subjects had significantly higher systolic blood pressure than the latter (mean rt SD, 146.0 +/- 25.0 vs 136.6 +/- 23.4; P = 0.032), These data suggest that genetic variation at the ESR2 locus may be associated with some determinants of blood pressure, and that there is a possible involvement of this polymorphism in causing hypertension in Japanese women.

引用

页码：327 / 330

页数：4

共 30 条

[1] Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: Effects on migration and proliferation of vascular smooth muscle cells [J].