Four cholesterol-sensing proteins

被引：34

作者：

Lange, Y

Steck, TL

机构：

[1] Rush Presbyterian St Lukes Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(98)80119-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

What is the connection among the following three medical conditions: Niemann-Pick type C disease (a cause of mental retardation and early death), systemic lipidosis (in which an obscure side effect of numerous drugs transforms lysosomes into lamellar bodies), and holoprosencephaly (a catastrophe in embryonic development)? Recent evidence suggests that the pathogenesis in each case involves impaired sensing of cellular cholesterol.

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页码：435 / 439

页数：5

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