Advances in magnetofection -: magnetically guided nucleic acid delivery

被引：115

作者：

Schillinger, U

Brill, T

Rudolph, C

Huth, S

Gersting, S

Krötz, F

Hirschberger, J

Bergemann, C

Plank, C

机构：

[1] Tech Univ Munich, Inst Expt Oncol, D-81675 Munich, Germany

[2] Univ Munich, Dept Pediat, D-80337 Munich, Germany

[3] Univ Munich, Inst Physiol, D-80336 Munich, Germany

[4] Univ Munich, Dept Vet Internal Med, D-80539 Munich, Germany

[5] Chemicell GmbH, D-10823 Berlin, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

magnetofection; gene therapy; gene delivery; magnetic drug targeting;

D O I：

10.1016/j.jmmm.2005.01.032

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acid shuttles (vectors) which are associated with magnetic nanoparticles. Recent progress with the method confirms its general applicability with small and large nucleic acids and viruses. The method's therapeutic application as well as mechanistic studies will be discussed. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：501 / 508

页数：8

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