Neutralizing antibodies in hepatitis C virus infection: A review of immunological and clinical characteristics

被引：17

作者：

Kaplan, M

Gawrieh, S

Cotler, SJ

Jensen, DM

机构：

[1] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Dept Internal Med, Sect Hepatol, Chicago, IL 60612 USA

[2] Cook Cty Hosp, Dept Med, Chicago, IL 60612 USA

来源：

GASTROENTEROLOGY | 2003年 / 125卷 / 02期

关键词：

D O I：

10.1016/S0016-5085(03)00882-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis C infection induces cross-reactive neutralizing antibodies that, in some cases, prevent primary infection in animal models. Neutralizing antibodies target the HVR1 of the E2 glycoprotein, and a conserved region at the C-terminus of HVR1 determines cross-reactivity. The humoral immune response appears to be the driving force leading to variability in HVR1, resulting in emergence of escape mutants and persistence of HCV infection. Advances in understanding the humoral response to HCV could facilitate development of a vaccine for hepatitis C as well as an effective HCIG preparation containing cross-reactive neutralizing antibodies to HCV.

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页码：597 / 604

页数：8

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