Effect of FGF-1 and FGF-2 on VEGF binding to human umbilical vein endothelial cells

被引：15

作者：

Chen, JH ^{[1
]}

Wang, XC

Kan, MK

Sato, JD

机构：

[1] Nanjing Univ, Dept Biochem, Pharmaceut Biotechnol Key Lab, Nanjing 210093, Peoples R China

[2] W Alton Jones Cell Sci Ctr Inc, Lake Placid, NY 12946 USA

来源：

CELL BIOLOGY INTERNATIONAL | 2001年 / 25卷 / 03期

关键词：

FGF-1; FGF-2; VEGF;

D O I：

10.1006/cbir.2000.0617

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

When FGF-1 or FGF-2 and VEGF were added together, the mitogenic effect of FGF-1 or FGF-2 and VEGF on HUVEC was additive. However, when HUVECs were preincubated for 2 days with 10 ng/ml FGF-1 in the absence of VEGF, the Scatchard plot of [I-125]VEGF binding sites was shifted to the right: both affinity classes of VEGF binding sites were equally affected, such that the total number of sites increased twofold. It is suggested that this type of interaction may be related to tumor angiogenesis and wound repair. (C) 2001 Academic Press.

引用

页码：257 / 260

页数：4

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