Subthreshold 5-Hz repetitive transcranial magnetic stimulation of the human primary motor cortex reduces intracortical paired-pulse inhibition

被引：74

作者：

Peinemann, A ^{[1
]}

Lehner, C

Mentschel, C

Münchau, A

Conrad, B

Siebner, HR

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

[2] Inst Neurol, MRC, Human Movement & Balance Unit, London WC1N 3BG, England

来源：

NEUROSCIENCE LETTERS | 2000年 / 296卷 / 01期

关键词：

intracortical facilitation; intracortical inhibition; motor cortex; paired-pulse; plasticity; transcranial magnetic stimulation;

D O I：

10.1016/S0304-3940(00)01616-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Paired-pulse transcranial magnetic stimulation (TMS) at short interstimulus intervals was employed to investigate short-term effects of 5-Hz repetitive TMS (rTMS) over the primary motor hand area (M1(HAND)) on intracortical excitability. In ten healthy individuals, 1250 pulses of 5-Hz rTMS were applied at 90% of motor resting threshold over the left M1(HAND) Ten minutes after 5-Hz rTMS, pal red-pulse inhibition was significantly reduced, whereas paired-pulse facilitation was not modified. Sham-rTMS had no lasting effect on intracortical excitability. These findings suggest that subthreshold 5-Hz rTMS causes a short-term modulation of the excitability of intracortical circuitry in the stimulated M1(HAND) The lasting effect of subthreshold 5-Hz rTMS on intracortical inhibition provides a useful probe for studying short-term plasticity of the human M1(HAND). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：21 / 24

页数：4

共 16 条

[1] Facilitation of muscle evoked responses after repetitive cortical stimulation in man [J].

Berardelli, A ;

Inghilleri, M ;

Rothwell, JC ;

Romeo, S ;

Currà, A ;

Gilio, F ;

Modugno, N ;

Manfredi, M .

EXPERIMENTAL BRAIN RESEARCH, 1998, 122 (01) :79-84

[2] Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].

Chen, R ;

Classen, J ;

Gerloff, C ;

Celnik, P ;

Wassermann, EM ;

Hallett, M ;

Cohen, LG .

NEUROLOGY, 1997, 48 (05) :1398-1403

[3]

Di Lazzaro V, 1998, EXP BRAIN RES, V119, P265

[4] CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].

KUJIRAI, T ;

CARAMIA, MD ;

ROTHWELL, JC ;

DAY, BL ;

THOMPSON, PD ;

FERBERT, A ;

WROE, S ;

ASSELMAN, P ;

MARSDEN, CD .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 :501-519

[5]

MEISTER IG, 2000, CLIN NEUROPHYSIOL, V111, pS114

[6]

MENTSCHEL C, 2000, CLIN NEUROPHYSIOL, V111, pS25

[7] Study and modulation of human cortical excitability with transcranial magnetic stimulation [J].

Pascual-Leone, A ;

Tormos, JM ;

Keenan, J ;

Tarazona, F ;

Cañete, C ;

Catalá, MD .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1998, 15 (04) :333-343

[8] RESPONSES TO RAPID-RATE TRANSCRANIAL MAGNETIC STIMULATION OF THE HUMAN MOTOR CORTEX [J].

PASCUALLEONE, A ;

VALLSSOLE, J ;

WASSERMANN, EM ;

HALLETT, M .

BRAIN, 1994, 117 :847-858

[9] NONINVASIVE ELECTRICAL AND MAGNETIC STIMULATION OF THE BRAIN, SPINAL-CORD AND ROOTS - BASIC PRINCIPLES AND PROCEDURES FOR ROUTINE CLINICAL-APPLICATION - REPORT OF AN IFCN COMMITTEE [J].

ROSSINI, PM ;

BARKER, AT ;

BERARDELLI, A ;

CARAMIA, MD ;

CARUSO, G ;

CRACCO, RQ ;

DIMITRIJEVIC, MR ;

HALLETT, M ;

KATAYAMA, Y ;

LUCKING, CH ;

DENOORDHOUT, ALM ;

MARSDEN, CD ;

MURRAY, NMF ;

ROTHWELL, JC ;

SWASH, M ;

TOMBERG, C .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1994, 91 (02) :79-92

[10] Lasting cortical activation after repetitive TMS of the motor cortex - A glucose metabolic study [J].

Siebner, HR ;

Peller, M ;

Willoch, F ;

Minoshima, S ;

Boecker, H ;

Auer, C ;

Drzezga, A ;

Conrad, B ;

Bartenstein, P .

NEUROLOGY, 2000, 54 (04) :956-963

← 1 2 →