Molecular pathology of wound healing

被引：261

作者：

Kondo, Toshikazu ^{[1
]}

Ishida, Yuko ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Forens Med, Wakayama, Japan

来源：

FORENSIC SCIENCE INTERNATIONAL | 2010年 / 203卷 / 1-3期

关键词：

Wound healing; Wound age; Growth factors; Cytokines; Bone marrow-derived cells; ENDOTHELIAL PROGENITOR CELLS; HUMAN SKIN WOUNDS; PROINFLAMMATORY CYTOKINES IL-1-BETA; MESSENGER-RNA EXPRESSION; REGULATED PROTEIN ORP150; FIBROBLAST-GROWTH-FACTOR; IMMUNOHISTOCHEMICAL LOCALIZATION; ESSENTIAL INVOLVEMENT; TEMPORAL EXPRESSION; AGE-DETERMINATION;

D O I：

10.1016/j.forsciint.2010.07.004

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

030101 [法学理论]; 030111 [法律史学]; 100218 [急诊医学];

摘要：

Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases, inflammation, proliferation, and maturation. Many biological substances are involved in the process of wound repair, and this short and simplified overview of wound healing can be adopted to determine wound vitality or wound age in forensic medicine. With the development of genetically engineered animals, essential molecules for skin-wound healing have been identified. Especially, cytokines, and growth factors are useful candidates and markers for the determination of wound vitality or age. Moreover, bone marrow-derived progenitor cells would give significant information to wound age determination. In this review article, some interesting observations are presented, possibly contributing to the future practice of forensic pathologists. (C) 2010 Published by Elsevier Ireland Ltd.

引用

页码：93 / 98

页数：6

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