Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

被引：85

作者：

Baik, Myunggi ^{[2
]}

Yu, Ji Hoon ^{[1
]}

Hennighausen, Lothar ^{[1
,2
]}

机构：

[1] NIH, Lab Genet & Physiol, Bethesda, MD 20892 USA

[2] Chonnam Natl Univ, WCU RNNM, Dept Mol Biotechnol, Kwangju, South Korea

来源：

NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER | 2011年 / 1229卷

关键词：

growth hormone; STAT5; liver function; I GENE-TRANSCRIPTION; LITHOCHOLIC ACID 6-BETA-HYDROXYLASE; SIGNAL TRANSDUCER; MOUSE-LIVER; MICROARRAY ANALYSIS; CELL-PROLIFERATION; SKELETAL-MUSCLE; EXPRESSION; STAT5B; ACTIVATION;

D O I：

10.1111/j.1749-6632.2011.06100.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The liver is a primary target of growth hormone (GH). GH signals arc mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

引用

收藏

页码：29 / 37

页数：9

相关论文

共 54 条

[1]

THE MOUSE 3-BETA-HYDROXYSTEROID DEHYDROGENASE MULTIGENE FAMILY INCLUDES 2 FUNCTIONALLY DISTINCT GROUPS OF PROTEINS [J].

ABBASZADE, IG ;

CLARKE, TR ;

PARK, CHJ ;

PAYNE, AH .

MOLECULAR ENDOCRINOLOGY, 1995, 9 (09) :1214-1222

[2]

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults) [J].

Alnouti, Yazen ;

Klaassen, Curtis D. .

XENOBIOTICA, 2011, 41 (03) :187-197

[3]

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism [J].

Barclay, Johanna L. ;

Nelson, Caroline N. ;

Ishikawa, Mayumi ;

Murray, Lauren A. ;

Kerr, Linda M. ;

McPhee, Timothy R. ;

Powell, Elizabeth E. ;

Waters, Michael J. .

ENDOCRINOLOGY, 2011, 152 (01) :181-192

[4]

Disruption of the Growth Hormone-Signal Transducer and Activator of Transcription 5-Insulinlike Growth Factor 1 Axis Severely Aggravates Liver Fibrosis in a Mouse Model of Cholestasis [J].

Blaas, Leander ;

Kornfeld, Jan-Wilhelm ;

Schramek, Daniel ;

Musteanu, Monica ;

Zollner, Gernot ;

Gumhold, Judith ;

van Zijl, Franziska ;

Schneller, Doris ;

Esterbauer, Harald ;

Egger, Gerda ;

Mair, Markus ;

Kenner, Lukas ;

Mikulits, Wolfgang ;

Eferl, Robert ;

Moriggl, Richard ;

Penninger, Josef ;

Trauner, Michael ;

Casanova, Emilio .

HEPATOLOGY, 2010, 51 (04) :1319-1326

[5]

Steroid hormones control circadian Elovl3 expression in mouse liver [J].

Brolinson, Annelie ;

Fourcade, Stephane ;

Jakobsson, Andreas ;

Pujol, Aurora ;

Jacobsson, Anders .

ENDOCRINOLOGY, 2008, 149 (06) :3158-3166

[6]

SOCS1 Links Cytokine Signaling to p53 and Senescence [J].

Calabrese, Viviane ;

Mallette, Frederick A. ;

Deschenes-Simard, Xavier ;

Ramanathan, Sheela ;

Gagnon, Julien ;

Moores, Adrian ;

Ilangumaran, Subburaj ;

Ferbeyre, Gerardo .

MOLECULAR CELL, 2009, 36 (05) :754-767

[7]

Identification of protein pheromones that promote aggressive behaviour [J].

Chamero, Pablo ;

Marton, Tobias F. ;

Logan, Darren W. ;

Flanagan, Kelly ;

Cruz, Jason R. ;

Saghatelian, Alan ;

Cravatt, Benjamin F. ;

Stowers, Lisa .

NATURE, 2007, 450 (7171) :899-U23

[8]

THE LITHOCHOLIC ACID 6-BETA-HYDROXYLASE CYTOCHROME-P-450, CYP 3A10, IS AN ACTIVE CATALYST OF STEROID-HORMONE 6-BETA-HYDROXYLATION [J].

CHANG, TKH ;

TEIXEIRA, J ;

GIL, G ;

WAXMAN, DJ .

BIOCHEMICAL JOURNAL, 1993, 291 :429-434

[9]

Dispersed Chromosomal Stat5b-binding Elements Mediate Growth Hormone-activated Insulin-like Growth Factor-I Gene Transcription [J].

Chia, Dennis J. ;

Varco-Merth, Ben ;

Rotwein, Peter .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (23) :17636-17647

[10]

Distinct Alterations in Chromatin Organization of the Two IGF-I Promoters Precede Growth Hormone-Induced Activation of IGF-I Gene Transcription [J].

Chia, Dennis J. ;

Young, Jennifer J. ;

Mertens, April R. ;

Rotwein, Peter .

MOLECULAR ENDOCRINOLOGY, 2010, 24 (04) :779-789

← 1 2 3 4 5 6 →