Clinical manifestations of mannan-binding lectin deficiency

被引：149

作者：

Thiel, S ^{[1
]}

Frederiksen, PD ^{[1
]}

Jensenius, JC ^{[1
]}

机构：

[1] Aarhus Univ, Dept Med Microbiol & Immunol, DK-8000 Aarhus, Denmark

来源：

MOLECULAR IMMUNOLOGY | 2006年 / 43卷 / 1-2期

关键词：

neutropenia; mannose-binding lectin; autoimmunity; sepsis; innate immunity;

D O I：

10.1016/j.molimm.2005.06.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune system. Ongoing research attempt to illuminate at which conditions MBL deficiency may lead to disease. With examples, this review illustrates the diversity of results obtained so far. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：86 / 96

页数：11

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