Mechanism of the tumor suppressive effect of MnSOD overexpression

被引：206

作者：

Oberley, LW ^{[1
]}

机构：

[1] Univ Iowa, Dept Radiat Oncol, Med Labs B180, Iowa City, IA 52242 USA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2005年 / 59卷 / 04期

关键词：

tumor suppressor; manganese-containing superoxide dismutase; glutathione peroxidase; catalase;

D O I：

10.1016/j.biopha.2005.03.006

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The mitochondrial antioxidant protein manganese-containing superoxide dismutase (MnSOD) has been shown to be a new type of tumor suppressor protein. Overexpression of MnSOD protein inhibits growth in a wide variety of cancer types. This review examines the molecular mechanism of the tumor suppressive effect of MnSOD. Three species have been proposed to cause the tumor suppressive effect: superoxide radical, hydrogen peroxide and nitric oxide. At the present time, the evidence appears strongest that hydrogen peroxide is the effector molecule since both catalase and glutathione peroxidase has been shown to modulate the effect. Surprisingly, in different cancer cell lines, overexpression of GPx has been found to both decrease and increase the growth inhibitory effect of MnSOD overexpression. Knowledge of which molecule causes the tumor suppressive effect of MnSOD and the mechanism of action will likely lead to new therapies for the treatment of cancer. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：143 / 148

页数：6

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