Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice

被引：59

作者：

Connolly, JM ^{[1
]}

Rose, DP ^{[1
]}

机构：

[1] Amer Hlth Fdn, Div Nutr & Endocrinol, Valhalla, NY 10595 USA

来源：

CANCER LETTERS | 1998年 / 132卷 / 1-2期

关键词：

breast cancer; MCF-7; cells; 12-lipoxygenase; cell proliferation; apoptosis; angiogenesis;

D O I：

10.1016/S0304-3835(98)00171-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. This enhanced acquisition of tumor mass was a result of both increased cell proliferation and reduced apoptotic cell death and was accompanied by high angiogenic activity. (C) 1998 Published by Elsevier Science ireland Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

共 32 条

[1] Apoptosis and proliferation in thyroid carcinoma: Correlation with bcl-2 and p53 protein expression [J].

Basolo, F ;

Pollina, L ;

Fontanini, G ;

Fiore, L ;

Pacini, F ;

Baldanzi, A .

BRITISH JOURNAL OF CANCER, 1997, 75 (04) :537-541

[2]

Choudhuri R, 1997, CANCER RES, V57, P1814

[3]

Claffey KP, 1996, CANCER RES, V56, P172

[4] TUMOR VASCULAR-PERMEABILITY FACTOR STIMULATES ENDOTHELIAL-CELL GROWTH AND ANGIOGENESIS [J].

CONNOLLY, DT ;

HEUVELMAN, DM ;

NELSON, R ;

OLANDER, JV ;

EPPLEY, BL ;

DELFINO, JJ ;

SIEGEL, NR ;

LEIMGRUBER, RM ;

FEDER, J .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (05) :1470-1478

[5]

Crew JP, 1997, CANCER RES, V57, P5281

[6] ARACHIDONIC-ACID METABOLITES IN BFGF-STIMULATED, PDGF-STIMULATED, AND SERUM-STIMULATED VASCULAR CELL-GROWTH [J].

DETHLEFSEN, SM ;

SHEPRO, D ;

DAMORE, PA .

EXPERIMENTAL CELL RESEARCH, 1994, 212 (02) :262-273

[7]

Domagala W, 1996, CLIN CANCER RES, V2, P147

[8] WHAT IS THE EVIDENCE THAT TUMORS ARE ANGIOGENESIS DEPENDENT [J].

FOLKMAN, J .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (01) :4-6

[9] Association of tumor angiogenesis with bone marrow micrometastases in breast cancer patients [J].

Fox, SB ;

Leek, RD ;

Bliss, J ;

Mansi, JL ;

Gusterson, B ;

Gatter, KC ;

Harris, AL .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (14) :1044-1049

[10]

Frankfurt OS, 1997, CLIN CANCER RES, V3, P465

← 1 2 3 4 →