SITC/iSBTc Cancer Immunotherapy Biomarkers Resource Document: Online resources and useful tools - a compass in the land of biomarker discovery

被引：23

作者：

Bedognetti, Davide ^{[1
,2
,3
,4
,5
]}

Balwit, James M. ^{[1
]}

Wang, Ena ^{[1
,2
,3
]}

Disis, Mary L. ^{[1
,6
]}

Britten, Cedrik M. ^{[7
,8
,9
,10
]}

Delogu, Lucia G. ^{[1
,11
]}

Tomei, Sara ^{[1
,2
,3
,12
,13
]}

Fox, Bernard A. ^{[1
,14
]}

Gajewski, Thomas F. ^{[1
,15
,16
]}

Marincola, Francesco M. ^{[1
,2
,3
]}

Butterfield, Lisa H. ^{[1
,17
,18
,19
]}

机构：

[1] Soc Immunotherapy Canc, Milwaukee, WI USA

[2] NIH, Infect Dis & Immunogenet Sect IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA

[3] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA

[4] Univ Genoa, Dept Internal Med DiMI, Genoa, Italy

[5] Natl Canc Res Inst Genoa, Dept Med Oncol, Genoa, Italy

[6] Univ Washington, Div Oncol, Tumor Vaccine Grp, Seattle, WA 98195 USA

[7] Johannes Gutenberg Univ Mainz, Dept Med, Univ Med Ctr, Mainz, Germany

[8] Ribological GmbH, Mainz, Germany

[9] Johannes Gutenberg Univ Mainz, Dept Internal Med, Univ Med Ctr, D-6500 Mainz, Germany

[10] BioNTech AG, Clin Dev, Mainz, Germany

[11] Univ Sassari, Dept Drug Sci, I-07100 Sassari, Italy

[12] Univ Pisa, Dept Oncol, Div Surg Mol & Ultrastruct Pathol, Pisa, Italy

[13] Pisa Univ Hosp, Pisa, Italy

[14] Providence Portland Med Ctr, Robert W Franz Canc Ctr, Earle A Chiles Res Inst, Lab Mol & Tumor Immunol, Portland, OR USA

[15] Univ Chicago, Dept Pathol, Hematol Oncol Sect, Chicago, IL 60637 USA

[16] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[17] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[18] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA

[19] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2011年 / 9卷

关键词：

WORKSHOP;

D O I：

10.1186/1479-5876-9-155

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Recent positive clinical results in cancer immunotherapy point to the potential of immune-based strategies to provide effective treatment of a variety of cancers. In some patients, the responses to cancer immunotherapy are durable, dramatically extending survival. Extensive research efforts are being made to identify and validate biomarkers that can help identify subsets of cancer patients that will benefit most from these novel immunotherapies. In addition to the clear advantage of such predictive biomarkers, immune biomarkers are playing an important role in the development, clinical evaluation and monitoring of cancer immunotherapies. This Cancer Immunotherapy Resource Document, prepared by the Society for Immunotherapy of Cancer (SITC, formerly the International Society for Biological Therapy of Cancer, iSBTc), provides key references and online resources relevant to the discovery, evaluation and clinical application of immune biomarkers. These key resources were identified by experts in the field who are actively pursuing research in biomarker identification and validation. This organized collection of the most useful references, online resources and tools serves as a compass to guide discovery of biomarkers essential to advancing novel cancer immunotherapies.

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