Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia

被引:51
作者
Breier, Joshua I. [1 ]
Juranek, Jenifer
Papanicolaou, Andrew C. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Ctr Clin Neurosci, Houston, TX USA
关键词
Aphasia; Therapy; Magnetoencephalography; Diffusion tensor imaging; Stroke; WHITE-MATTER TRACTS; DIFFUSION TENSOR; FIBER DENSITY; STROKE; DEGENERATION; ACTIVATION; RECOVERY; REHABILITATION; OPTIMIZATION; PLASTICITY;
D O I
10.1080/13554794.2010.547505
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
A patient with chronic aphasia secondary to unilateral stroke in the left hemisphere underwent language testing, diffusion tensor imaging (DTI), and functional imaging using magnetoencephalography (MEG) at four time points: 3 weeks prior to, immediately prior to, immediately after, and 3 months after Constraint Induced Language Therapy (CILT). Performance on language tests involving visual naming and repetition of spoken sentences improved between the immediately prior to and immediately after CILT testing sessions, but not between the pre-CILT sessions. MEG activation in putative pre-morbid language areas of the left hemisphere and homotopic areas of the right hemisphere increased immediately after therapy, as did integrity within the arcuate fasciculus bilaterally. These changes were not evident between the two pre-CILT sessions. While some of these functional, neurophysiological and structural changes had regressed 3 months after therapy, all remained at or above baseline levels. Results provide evidence for an association between improvement in functional status and the increased integrity within a white matter tract known to be involved in language function and its contralateral homologue, as well as increased neurophysiological activity in areas that have the potential to subserve language function bilaterally.
引用
收藏
页码:506 / 517
页数:12
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