Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study

被引：283

作者：

Patel, NK

Bunnage, M

Plaha, P

Svendsen, CN

Heywood, P

Gill, SS ^{[1
]}

机构：

[1] Frenchay Hosp, Dept Neurosurg, Inst Neurosci, Bristol BS16 1LE, Avon, England

[2] Univ Wisconsin, Waisman Ctr Stem Cell Res Program, Madison, WI USA

[3] Univ Wisconsin, Dept Neurol, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Anat, Madison, WI 53706 USA

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 02期

关键词：

D O I：

10.1002/ana.20374

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have shown previously that intraparenchymal infusion of glial cell line-derived neurotrophic factor (GDNF) continuously into the posterior putamen in five Parkinson's disease patients is safe and may represent a new treatment option. Here, we report a continuation of this phase I study. After 2 years of continual GDNF infusion, there were no serious clinical side effects and no significant detrimental effects on cognition. Patients showed a 57% and 63% improvement in their off-medication motor and activities of daily living subscores of the Unified Parkinson's Disease Rating Scale, respectively, and health-related quality-of-life measures (Parkinson's Disease Questionnaire-39 and Short Form-36) showed general improvement over time.

引用

页码：298 / 302

页数：5

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