Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke

被引：68

作者：

Dotson, Abby L. ^{[1
,2
]}

Wang, Jianming ^{[3
]}

Saugstad, Julie ^{[3
]}

Murphy, Stephanie J. ^{[3
]}

Offner, Halina ^{[1
,2
,3
]}

机构：

[1] VA Med Ctr, Portland, OR USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97201 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 278卷

关键词：

Experimental stroke; Sex difference; Immune response; Neuroinflammation; Infarct volume; Splenectomy; REGULATORY T-CELLS; ACUTE ISCHEMIC-STROKE; NECROSIS-FACTOR-ALPHA; BRAIN-INJURY; CEREBRAL-ISCHEMIA; INFLAMMATION; SEX; EXPRESSION; PROTECTS; ESTROGEN;

D O I：

10.1016/j.jneuroim.2014.11.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The peripheral immune response contributes to neurodegeneration after stroke yet little is known about how this process differs between males and females. The current study demonstrates that splenectomy prior to experimental stroke eliminates sex differences in infarct volume and activated brain monocytes/microglia. In the periphery of both sexes, activated T cells correlate directly with stroke outcome while monocytes are reduced by splenectomy only in males. This study provides new information about the sex specific mechanisms of the peripheral immune response in neurodegeneration after stroke and demonstrates the need for representation of both sexes in basic and clinical stroke research. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：289 / 298

页数：10

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