Advances in Anticancer Immunotoxin Therapy

被引：153

作者：

Alewine, Christine ^{[1
]}

Hassan, Raffit ^{[2
]}

Pastan, Ira ^{[1
]}

机构：

[1] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

[2] NCI, Thorac & Gastrointestinal Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ONCOLOGIST | 2015年 / 20卷 / 02期

关键词：

Antibody conjugate; Recombinant immunotoxin; Vascular leak syndrome; Antidrug antibody; PHASE-I TRIAL; TRIPLE-NEGATIVE BREAST; VASCULAR LEAK SYNDROME; RECOMBINANT IMMUNOTOXIN; ANTIBODY-RICIN; DENILEUKIN DIFTITOX; MALIGNANT-MELANOMA; PLUS CYCLOPHOSPHAMIDE; MESOTHELIN EXPRESSION; PSEUDOMONAS EXOTOXIN;

D O I：

10.1634/theoncologist.2014-0358

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical development for a variety of malignancies. They consist of an antibody-based targeting domain fused to a bacterial toxin payload for cell killing. Immunotoxins kill cellsbyinhibiting protein synthesis, aunique mechanism of action that is toxic to both dividing and nondividing cells. Recent advances in the design and administration of immunotoxins are overcoming historical challenges in the field, leading torenewedinterest in these therapeutics.

引用

收藏

页码：176 / 185

页数：10

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