A tau promoter region without neuronal specificity

被引：44

作者：

Andreadis, A

Wagner, BK

Broderick, JA

Kosik, KS

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROL NEUROSCI,BOSTON,MA 02115

[2] BRIGHAM & WOMENS HOSP,CTR NEUROL DIS,DEPT MED,DIV NEUROL,BOSTON,MA 02115

来源：

JOURNAL OF NEUROCHEMISTRY | 1996年 / 66卷 / 06期

关键词：

microtubule-associated protein tau; 5'-untranslated region; homogeneous initiation sites; promoter mapping; specificity of expression;

D O I：

10.1046/j.1471-4159.1996.66062257.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microtubule-associated protein tau is produced from a 6-kb mRNA expressed primarily in neurons. A 2-kb tau mRNA has also been characterized, which produces a tau isoform that localizes to the nucleus, and an 8-kb mRNA is expressed in the PNS, Mapping and sequencing of the human tau gene start showed that it has an unusually GC-rich 5'-untranslated region coded by a single untranslated exon (designated -1), Primer extensions and expression assays indicated that upstream of exon -1 is a promoter that is not neuron specific. This region contains consensus binding sites for transcription factors AP2, Sp1, and GCF.

引用

页码：2257 / 2263

页数：7

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