Confirmation of organized modularity in the yeast interactome

被引：77

作者：

Bertin, Nicolas

Simonis, Nicolas

Dupuy, Denis

Cusick, Michael E.

Han, Jing-Dong J.

Fraser, Hunter B.

Roth, Frederick P.

Vidal, Marc

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] Chinese Acad Sci, Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China

[5] Harvard Univ, Broad Inst, Cambridge, MA 02138 USA

[6] MIT, Cambridge, MA 02139 USA

[7] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA USA

来源：

PLOS BIOLOGY | 2007年 / 5卷 / 06期

关键词：

D O I：

10.1371/journal.pbio.0050153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We confirmed that date and party hubs have different topological properties, with the coordinating role of date hubs being supported by a greater impact on CPL. We also confirmed that date hubs participate in more genetic interactions and evolve more rapidly than party hubs. These observations, as well as the identity of the nodes considered as date and party, remained largely consistent within all tested networks (HC, filtered-HC, HCfyi), demonstrating the robustness of the results originally observed in [2]. Thus, this updated analysis confirms the validity of the distinction between date and party hubs in the yeast interactome [2,3], and shows that the date and party hub concept and the stratus-like" network [1] model are not mutually exclusive. © 2007 Bertin et al."

引用

页码：1206 / 1210

页数：5

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