Site directed maleimide bifunctional chelators for the M(CO)3+ core (M=99mTc, Re)

被引：29

作者：

Banerjee, SR

Babich, JW

Zubieta, J ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

[2] Mol Insight Pharmaceut, Cambridge, MA 02142 USA

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 13期

关键词：

D O I：

10.1039/b417588c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of bifunctional chelates containing a tridentate donor set for complexation of the M(CO)(3)(+) core and a maleimide group for site-specific coupling to peptides and proteins containing free thiol groups has been prepared and their Re(CO)(3)(+) complexes and glutathione conjugates structurally characterized. The flexibility of design allows preparation of ligands suitable for both fluorescence imaging, radioimaging and radiotherapeutic studies of proteins and peptides as well as other biopolymers using site specific conjugation.

引用

收藏

页码：1784 / 1786

页数：3

相关论文

共 28 条

[1] SYNTHESIS AND REACTIVITY OF [NET4]2[REBR3(CO)3] - FORMATION AND STRUCTURAL CHARACTERIZATION OF THE CLUSTERS [NET4][RE3(MU-3-OH)(MU-OH)3(CO)9] AND [NET4][RE2(MU-OH)3(CO)6] BY ALKALINE TITRATION [J].

ALBERTO, R ;

EGLI, A ;

ABRAM, U ;

HEGETSCHWEILER, K ;

GRAMLICH, V ;

SCHUBIGER, PA .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1994, (19) :2815-2820

[2] A novel organometallic aqua complex of technetium for the labeling of biomolecules:: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in aqueous solution and its reaction with a bifunctional ligand [J].

Alberto, R ;

Schibli, R ;

Egli, A ;

Schubiger, AP ;

Abram, U ;

Kaden, TA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (31) :7987-7988

[3]

Alberto R., 2004, COMPREHENSIVE COORDI, P127, DOI DOI 10.1016/B0-08-043748-6/04022-6

[4] Recent advances in 99mTc radio pharmaceuticals [J].

Arano, Y .

ANNALS OF NUCLEAR MEDICINE, 2002, 16 (02) :79-93

[5] Evolution of Tc-99m in diagnostic radiopharmaceuticals [J].

Banerjee, S ;

Pillai, MRA ;

Ramamoorthy, N .

SEMINARS IN NUCLEAR MEDICINE, 2001, 31 (04) :260-277

[6] Bifunctional single amino acid chelates for labeling of biomolecules with the {Tc(CO)3}+ and {Re(CO)3}+ cores.: Crystal and molecular structures of [ReBr(CO)3(H2NCH2C5H4N)], [Re(CO)3{(C5H4NCH2)2NH}]Br, [Re(CO)3{(C5H4NCH2)2NCH2CO2H}]Br, [Re(CO)3{X(Y)NCH2CO2CH2CH3}]Br (X = Y=2-pyridylmethyl; X=2-pyridyimethyl, Y=2-(1-methylimidazolyl)methyl; X = Y=2-(1-methylimidazolyl)methyl), [ReBr(CO)3{(C5H4NCH2)NH(CH2C4H3S)}], and [Re(CO)3{(C5H4NCH2)N(CH2C4H3S)(CH2CO2)}] [J].

Banerjee, SR ;

Levadala, MK ;

Lazarova, N ;

Wei, LH ;

Valliant, JF ;

Stephenson, KA ;

Babich, JW ;

Maresca, KP ;

Zubieta, J .

INORGANIC CHEMISTRY, 2002, 41 (24) :6417-6425

[7]

Blower PJ, 1999, PERSP BIOIN, V4, P91

[8]

CASTRONOVO FP, 1972, J NUCL MED, V13, P823

[9] Therapeutic antibody fragments with prolonged in vivo half-lives [J].

Chapman, AP ;

Antoniw, P ;

Spitali, M ;

West, S ;

Stephens, S ;

King, DJ .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :780-783

[10]

FISCHMAN AJ, 1993, J NUCL MED, V34, P2253