Antimicrobial and anti-inflammatory actions of tea-leaf saponin

被引：51

作者：

Sagesaka, YM ^{[1
]}

Uemura, T ^{[1
]}

Suzuki, Y ^{[1
]}

Sugiura, T ^{[1
]}

Yoshida, M ^{[1
]}

Yamaguchi, K ^{[1
]}

Kyuki, K ^{[1
]}

机构：

[1] NIHON BIORES CTR INC, HASHIMA LAB, GIFU 50162, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1996年 / 116卷 / 03期

关键词：

saponin; tea; anti-inflammatory; antimicrobial action; Camellia sinensis; hyaluronidase; leukotrien D-4;

D O I：

10.1248/yakushi1947.116.3_238

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antimicrobial and anti-inflammatory actions of tea-leaf saponin, which was a mixture of saponin separated from leaves of Camellia sinensis var. sinensis, were investigated. Tea-leaf saponin showed relatively high antimicrobial activity against pathogenic dermal fungi and its MIC value for Microsporum audouinii was 10 mu g/ml. On the other hand, tea-leaf saponin inhibited rat paw edema induced by carrageenin in a dose dependent manner. Activation of hyaluronidase, one of the enzymes involved in inflammatory reactions, was inhibited by tea-leaf saponin. It was also found that tea-leaf saponin antagonized the action of leukotrien D-4, one of the chemical mediators of inflammatory reactions. Any symptom of toxic reaction was not observed when tea-leaf saponin was administered orally to mice at a dose of 2000 mg/kg.

引用

页码：238 / 243

页数：6