Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

被引：38

作者：

Battistella, Claudia ^{[1
,2
]}

Klok, Harm-Anton ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Mat, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, Lab Polymeres, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

来源：

MACROMOLECULAR BIOSCIENCE | 2017年 / 17卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

cytosolic delivery; intracellular trafficking; organelle delivery; polymer conjugates and nanoparticles; polymer nanomedicines; IN-VITRO CYTOTOXICITY; NUCLEAR-LOCALIZATION SIGNAL; TRIGGERED DRUG-RELEASE; GENE DELIVERY; BLOCK-COPOLYMERS; CHARGE-REVERSAL; PLASMID DNA; SYNERGISTIC ACTION; HYDRAZONE LINKAGE; ENDOSOMAL ESCAPE;

D O I：

10.1002/mabi.201700022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well-defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.

引用

页数：26

共 239 条

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