Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function

被引：115

作者：

Teixeira, Antonio Lucio ^{[1
]}

Barbosa, Izabela Guimaraes ^{[1
]}

Diniz, Breno Satler ^{[2
]}

Kummer, Arthur ^{[1
]}

机构：

[1] Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Imunofarmacol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Neurosci Lab UM 27, BR-05403010 Sao Paulo, Brazil

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 06期

关键词：

Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; brain-derived neurotrophic factor; depression; Huntington's disease; Parkinson's disease; plasma; serum; AMYOTROPHIC-LATERAL-SCLEROSIS; BDNF VAL66MET POLYMORPHISM; INDUCED ARC EXPRESSION; NERVE GROWTH-FACTOR; DEVELOPING HIPPOCAMPAL-NEURONS; AMYLOID PRECURSOR PROTEIN; DISEASE SUBSTANTIA-NIGRA; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; BIPOLAR DISORDER;

D O I：

10.2217/BMM.10.111

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimer's disease, Huntington's disease and Parkinson's disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.

引用

页码：871 / 887

页数：17

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