The capnellenes revisited: New structures and new biological activity

被引：22

作者：

Morris, LA

Jaspars, M ^{[1
]}

Adamson, K

Woods, S

Wallace, HM

机构：

[1] Univ Aberdeen, Dept Chem, Marine Nat Prod Lab, Old Aberdeen AB24 3UE, Scotland

[2] Univ Aberdeen, Dept Biomed Sci, Aberdeen AB25 2ZD, Scotland

[3] Univ Aberdeen, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland

来源：

TETRAHEDRON | 1998年 / 54卷 / 42期

关键词：

D O I：

10.1016/S0040-4020(98)00784-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three capnellanes have been isolated fi om the soft coral Capnella imbricata. one known (1) and two new structures (9, 10). Their structures were determined by a mixture of spectroscopic methods and comparisons to the previous literature. Cytotoxicity against a panel of cancer cell lines was determined for all the compounds with compound 1 showing an IC50 of 0.7 mu M against K562 leukaemia. In addition compound 9 was cytotoxic to promyelogenous leukaemia and 10 was active against renal leiomyoblastoma cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：12953 / 12958

页数：6

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