Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory

被引：186

作者：

Barrett, Ruth M. ^{[1
]}

Malvaez, Melissa ^{[1
]}

Kramar, Eniko ^{[2
]}

Matheos, Dina P. ^{[1
]}

Arrizon, Abraham ^{[1
]}

Cabrera, Sara M. ^{[3
]}

Lynch, Gary ^{[2
]}

Greene, Robert W. ^{[4
,5
]}

Wood, Marcelo A. ^{[1
]}

机构：

[1] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Dept Neurobiol & Behav, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Psychiat, Irvine, CA 92697 USA

[3] Allergan, Dept Biol Sci, Irvine, CA USA

[4] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[5] Dallas Vet Adm Med Ctr, Dallas, TX USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2011年 / 36卷 / 08期

关键词：

CBP; histone acetylation; long-term memory; long-term potentiation; RUBINSTEIN-TAYBI-SYNDROME; CREB-BINDING-PROTEIN; SYNAPTIC PLASTICITY; TRANSCRIPTIONAL COACTIVATOR; OBJECT-RECOGNITION; CONTEXTUAL FEAR; NEURONAL DEGENERATION; DIFFERENT REGIONS; HDAC INHIBITION; NMDA RECEPTORS;

D O I：

10.1038/npp.2011.61

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone modifications, gene expression, synaptic plasticity, and long-term memory. We show that CBP is critical for the in vivo acetylation of lysines on histones H2B, H3, and H4. CBP's homolog p300 was unable to compensate for the loss of CBP. Neurons lacking CBP maintained phosphorylation of the transcription factor CREB, yet failed to activate CREB: CBP-mediated gene expression. Loss of CBP in dorsal CA1 of the hippocampus resulted in selective impairments to long-term potentiation and long-term memory for contextual fear and object recognition. Together, these results suggest a necessary role for specific chromatin modifications, selectively mediated by CBP in the consolidation of memories. Neuropsychopharmacology (2011) 36, 1545-1556; doi:10.1038/npp.2011.61; published online 20 April 2011

引用

页码：1545 / 1556

页数：12

共 70 条

[1]

Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice:: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration [J].

Alarcón, JM ;

Malleret, G ;

Touzani, K ;

Vronskaya, S ;

Ishii, S ;

Kandel, ER ;

Barco, A .

NEURON, 2004, 42 (06) :947-959

[2]

Transcription Factors in Long-Term Memory and Synaptic Plasticity [J].

Alberini, Cristina M. .

PHYSIOLOGICAL REVIEWS, 2009, 89 (01) :121-145

[3]

A FAMILY OF TRANSCRIPTIONAL ADAPTER PROTEINS TARGETED BY THE E1A ONCOPROTEIN [J].

ARANY, Z ;

NEWSOME, D ;

OLDREAD, E ;

LIVINGSTON, DM ;

ECKNER, R .

NATURE, 1995, 374 (6517) :81-84

[4]

The consolidation of object and context recognition memory involve different regions of the temporal lobe [J].

Balderas, Israela ;

Rodriguez-Ortiz, Carlos J. ;

Salgado-Tonda, Paloma ;

Chavez-Hurtado, Julio ;

McGaugh, James L. ;

Bermudez-Rattoni, Federico .

LEARNING & MEMORY, 2008, 15 (09) :618-624

[5]

Beyond transcription factors: The role of chromatin modifying enzymes in regulating transcription required for memory [J].

Barrett, Ruth M. ;

Wood, Marcelo A. .

LEARNING & MEMORY, 2008, 15 (07) :460-467

[6]

A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4 [J].

Bourtchouladze, R ;

Lidge, R ;

Catapano, R ;

Stanley, J ;

Gossweiler, S ;

Romashko, D ;

Scott, R ;

Tully, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10518-10522

[7]

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system [J].

Burger, C ;

Gorbatyuk, OS ;

Velardo, MJ ;

Peden, CS ;

Williams, P ;

Zolotukhin, S ;

Reier, PJ ;

Mandel, RJ ;

Muzyczka, N .

MOLECULAR THERAPY, 2004, 10 (02) :302-317

[8]

CBP: A signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV [J].

Chawla, S ;

Hardingham, GE ;

Quinn, DR ;

Bading, H .

SCIENCE, 1998, 281 (5382) :1505-1509

[9]

CREB Binding Protein Is Required for Both Short-Term and Long-Term Memory Formation [J].

Chen, Guiquan ;

Zou, Xiaoyan ;

Watanabe, Hirotaka ;

van Deursen, Jan M. ;

Shen, Jie .

JOURNAL OF NEUROSCIENCE, 2010, 30 (39) :13066-13077

[10]

The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation [J].

Chwang, Wilson B. ;

Arthur, J. Simon ;

Schumacher, Armin ;

Sweatt, J. David .

JOURNAL OF NEUROSCIENCE, 2007, 27 (46) :12732-12742

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