Inclusion complex formation of antisense nucleotides with hydroxypropyl-beta-cyclodextrin

被引：22

作者：

Cserhati, T ^{[1
]}

Forgacs, E ^{[1
]}

Szejtli, J ^{[1
]}

机构：

[1] CYCLOLAB RES & DEV LAB,BUDAPEST,HUNGARY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 141卷 / 1-2期

关键词：

antisense nucleosides; hydroxypropyl-beta-cyclodextrin; hydrophobic interaction;

D O I：

10.1016/0378-5173(96)04583-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction between 26 nucleoside derivatives and hyroxypropyl-beta-cyclodextrin (HPBCD) was determined by charge-transfer chromatography. HPBCD interacted with each nucleoside decreasing the lipophilicity of the guest molecules. Both sterical (specific hydrophobic surface area) and hydrophobicity parameters of nucleosides influenced the strength of interaction. Substituents with longer alkyl chain considerably increased the strength af interaction whereas the effect of double or triple bond in the chain was negligible.

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页码：1 / 7

页数：7

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