The role of endosymbiotic Wolbachia bacteria in filarial disease

被引：45

作者：

Hise, AG

Gillette-Ferguson, I

Pearlman, E

机构：

[1] Case Western Reserve Univ, Sch Med, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Visual Sci Res Ctr, Cleveland, OH 44106 USA

来源：

CELLULAR MICROBIOLOGY | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1046/j.1462-5822.2003.00350.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this review, we describe the pathogenic role of Wolbachia endosymbiotic bacteria in filarial diseases, focusing on the host innate immune responses to filarial and Wolbachia products. A description of the host pathogen recognition and early inflammatory responses including TLR4-mediated signalling, chemokine and cytokine responses and inflammatory cell recruitment is provided from human studies and from animal models of filarial disease. Finally, the impact of the discovery and characterization of Wolbachia on filarial research and treatment programmes is discussed.

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页码：97 / 104

页数：8

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