An update on antigenic variation in African trypanosomes

被引：74

作者：

Vanhamme, L

Pays, E

McCulloch, R

Barry, JD

机构：

[1] Free Univ Brussels, IBMM, Mol Parasitol Lab, B-6041 Gosselies, Belgium

[2] Univ Glasgow, Anderson Coll, Wellcome Ctr Mol Parasitol, Glasgow G11 6NU, Lanark, Scotland

来源：

TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1471-4922(01)01922-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

African trypanosomes can spend a long time in the blood of their mammalian host,where they are exposed to the immune system and are thought to take advantage of it to modulate their own numbers. Their major immunogenic protein is the variant surface glycoprotein (VSG), the gene for which must be in one of tbe 20-40 specialized telomeric expression sites in order to be transcribed. Trypanosomes escape antibody-mediated destruction through periodic changes of the expressed VSG gene from a repertoire of similar to 1000. How do trypanosomes exclusively express only one VSG and how do they switch between them?

引用

收藏

页码：338 / 343

页数：6

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