Lactate: Biomarker and Potential Therapeutic Target

被引：184

作者：

Okorie, Okorie Nduka ^{[1
,2
]}

Dellinger, Phil ^{[3
,4
]}

机构：

[1] Orlando Reg Med Ctr Inc, Dept Crit Care Med, Orlando, FL USA

[2] Florida State Univ, Sch Med, Orlando, FL USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Camden, NJ 08103 USA

[4] Cooper Univ Hosp, Div Crit Care Med, Camden, NJ USA

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 02期

关键词：

Lactate; Hypoperfusion; Critically ill; Biomarker; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; VENOUS OXYGEN-SATURATION; ACUTELY INJURED PATIENT; MULTIPLE ORGAN FAILURE; CAPILLARY REFILL TIME; ACUTE LIVER-FAILURE; STRONG ION GAP; BLOOD LACTATE; SERUM LACTATE;

D O I：

10.1016/j.ccc.2010.12.013

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Lactate levels are frequently elevated in critically ill patients and correlate well with disease severity. Elevated lactate levels are prognostic in prehospital, emergency department, and intensive care unit settings. This review discusses the role of lactate as a biomarker in diagnosing and assessing the severity of systemic hypoperfusion, as well as the role of serum lactate measurements in guiding clinical care and enabling prognosis in critically ill patients.

引用

页码：299 / +

页数：29

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