Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

被引:40
作者
Burden, Natalie [1 ]
Sewell, Fiona [1 ]
Chapman, Kathryn [1 ]
机构
[1] NC3Rs, London, England
关键词
OPPORTUNITIES; MODELS;
D O I
10.1371/journal.pbio.1002156
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Scientists face growing pressure to move away from using traditional animal toxicity tests to determine whether manufactured chemicals are safe. Numerous ethical, scientific, business, and legislative incentives will help to drive this shift. However, a number of hurdles must be overcome in the coming years before non-animal methods are adopted into widespread practice, particularly from regulatory, scientific, and global perspectives. Several initiatives are nevertheless underway that promise to increase the confidence in newer alternative methods, which will support the move towards a future in which less data from animal tests is required in the assessment of chemical safety.
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收藏
页数:8
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