A new allelic series for the underwhite gene on mouse chromosome 15

被引:28
作者
Sweet, HO
Brilliant, MH
Cook, SA
Johnson, KR
Davisson, MT
机构
[1] Jackson Lab, Bar Harbor, ME 04609 USA
[2] Univ Arizona, Hlth Sci Ctr, Dept Pediat, Tucson, AZ 85721 USA
关键词
D O I
10.1093/jhered/89.6.546
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A new allelic series at the underwhite gene is described. Three of the alleles in the series-uw, uw(d), and Uw(dbr)-arose as spontaneous mutations on different genetic backgrounds at The Jackson Laboratory. We report here the visible phenotypes and dominance hierarchy of these alleles, all of which are defined by a reduction of pigmentation in both eye and coat color. Electron microscopic analysis of retinal epithelium suggests that the primary defect is in the melanosome. The degree of severity of melanosome anomalies in the retina correlates with the degree or hypopigmentation in the coat. The perturbed gene and its gene product are unknown. We show that the uw locus is genetically distinct from Myo10, a suggested candidate gene for this mutation.
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页码:546 / 551
页数:6
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