Functional evaluation of peripheral nerve regeneration in the rat:: walking track analysis

被引：267

作者：

Varejao, ASP ^{[1
]}

Meek, MF

Ferreira, AJA

Patrício, JAB

Cabrita, AMS

机构：

[1] UTAD, Dept Pathol, Vila Real, Portugal

[2] UTAD, Vet Clin, Vila Real, Portugal

[3] Univ Groningen Hosp, Dept Plast Surg, Groningen, Netherlands

[4] Fac Vet Med, Lisbon, Portugal

[5] Univ Hosp Coimbra, Lab Anim Experimentat, Coimbra, Portugal

[6] Fac Med, CHPEBD, Inst Pathol Anat, Coimbra, Portugal

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2001年 / 108卷 / 01期

关键词：

peripheral nerve regeneration; rat sciatic nerve; functional nerve recovery; walking track analysis; toe spread; limitations of sciatic function index;

D O I：

10.1016/S0165-0270(01)00378-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The experimental model of choice for many peripheral nerve investigators is the rat. Walking track analysis is a useful tool in the evaluation of functional peripheral nerve recovery in the rat. This quantitative method of analyzing hind limbs performance by examining footprints, known as the sciatic function index (SFI), has been widely used to quantify functional recovery from sciatic nerve injury in a number of different injury models, although some limitations of the SFI has been questioned by several authors. This article is designed to offer the peripheral nerve investigator a noninvasive method to evaluate quantitatively the integrated motor recovery in experimental studies. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 9

页数：9

共 79 条

[1] Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells [J].