High- and low-frequency repetitive transcranial magnetic stimulation differentially activates c-Fos and zif268 protein expression in the rat brain

被引：167

作者：

Aydin-Abidin, Selcen ^{[1
,2
]}

Trippe, Joern ^{[1
]}

Funke, Klaus ^{[1
]}

Eysel, Ulf T. ^{[1
]}

Benali, Alia ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Fac Med, Dept Neurophysiol, D-44780 Bochum, Germany

[2] Ruhr Univ Bochum, Int Grad Sch Neurosci, D-44780 Bochum, Germany

来源：

EXPERIMENTAL BRAIN RESEARCH | 2008年 / 188卷 / 02期

关键词：

cortex; cortical activation; immediate early genes; limbic system; stimulation-frequency; repetitive TMS; synaptic plasticity;

D O I：

10.1007/s00221-008-1356-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) has been shown to alter cortical excitability depending on the stimulus-frequency used, with high frequency (5 Hz and higher) increasing it but low frequency (usually 1 Hz or lower) reducing it. To determine the efficiency of different rTMS protocols in inducing cortical network activity, we tested the acute effect of one low-frequency rTMS protocol (1 Hz) and two different high-frequency protocols (10 Hz and intermittent theta-burst stimulation, iTBS) on the expression of the two immediate early gene (IEG) proteins c-Fos and zif268 in the rat brain. The cortical expression of both IEGs was specifically changed in an rTMS-dependent manner. One and 10 Hz rTMS enhanced c-Fos protein expression in all cortical areas tested, while iTBS was effective only in limbic cortices. Zif268 expression was increased in almost all cortical areas after iTBS, while 10 Hz rTMS was effective only in the primary motor and sensory cortices. One Hertz rTMS had no effect on cortical zif268 expression. Furthermore, sham-rTMS had no effect on zif268 expression but increased c-Fos in limbic cortices. This is the first study demonstrating that cortical zif268 and c-Fos expression can be specifically modulated by acute rTMS depending on the pattern of stimulation applied.

引用

页码：249 / 261

页数：13

共 54 条

[1] IMMEDIATE-EARLY GENE-EXPRESSION ASSOCIATED WITH THE PERSISTENCE OF HETEROSYNAPTIC LONG-TERM DEPRESSION IN THE HIPPOCAMPUS [J].

ABRAHAM, WC ;

CHRISTIE, BR ;

LOGAN, B ;

LAWLOR, P ;

DRAGUNOW, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :10049-10053

[2] CORRELATIONS BETWEEN IMMEDIATE-EARLY GENE INDUCTION AND THE PERSISTENCE OF LONG-TERM POTENTIATION [J].

ABRAHAM, WC ;

MASON, SE ;

DEMMER, J ;

WILLIAMS, JM ;

RICHARDSON, CL ;

TATE, WP ;

LAWLOR, PA ;

DRAGUNOW, M .

NEUROSCIENCE, 1993, 56 (03) :717-727

[3] Effects of repetitive TMS on visually evoked potentials and EEG in the anaesthetized cat: dependence on stimulus frequency and train duration [J].

Aydin-Abidin, Selcen ;

Moliadze, Vera ;

Eysel, Ulf T. ;

Funke, Klaus .

JOURNAL OF PHYSIOLOGY-LONDON, 2006, 574 (02) :443-455

[4] A computerized image analysis system for quantitative analysis of cells in histological brain sections [J].

Benali, A ;

Leefken, I ;

Eysel, UT ;

Weiler, E .

JOURNAL OF NEUROSCIENCE METHODS, 2003, 125 (1-2) :33-43

[5] Transcranial magnetic stimulation induces alterations in brain monoamines [J].

BenShachar, D ;

Belmaker, RH ;

Grisaru, N ;

Klein, E .

JOURNAL OF NEURAL TRANSMISSION, 1997, 104 (2-3) :191-197

[6] OPTIMAL FOCAL TRANSCRANIAL MAGNETIC ACTIVATION OF THE HUMAN MOTOR CORTEX - EFFECTS OF COIL ORIENTATION, SHAPE OF THE INDUCED CURRENT PULSE, AND STIMULUS-INTENSITY [J].

BRASILNETO, JP ;

COHEN, LG ;

PANIZZA, M ;

NILSSON, J ;

ROTH, BJ ;

HALLETT, M .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1992, 9 (01) :132-136

[7] Dual activity maps in primate visual cortex produced by different temporal patterns of zif268 mRNA and protein expression [J].

Chaudhuri, A ;

Nissanov, J ;

Larocque, S ;

Rioux, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2671-2675

[8] Burst stimulation of the medial forebrain bundle selectively increases Fos-like immunoreactivity in the limbic forebrain of the rat [J].

Chergui, K ;

Nomikos, GG ;

Mathe, JM ;

Gonon, F ;

Svensson, TH .

NEUROSCIENCE, 1996, 72 (01) :141-156

[9] RAPID INCREASE OF AN IMMEDIATE EARLY GENE MESSENGER-RNA IN HIPPOCAMPAL-NEURONS BY SYNAPTIC NMDA RECEPTOR ACTIVATION [J].

COLE, AJ ;

SAFFEN, DW ;

BARABAN, JM ;

WORLEY, PF .

NATURE, 1989, 340 (6233) :474-476

[10] How necessary is the activation of the immediate early gene zif 268 in synaptic plasticity and learning? [J].

Davis, S ;

Bozon, B ;

Laroche, S .

BEHAVIOURAL BRAIN RESEARCH, 2003, 142 (1-2) :17-30

← 1 2 3 4 5 6 →