Aberrant expression of p21WAF1/CIP1 and p27KIP1 in cervical carcinoma

被引：47

作者：

Cheung, TH ^{[1
]}

Lo, KWK

Yu, MMY

Yim, SF

Poon, CS

Chung, TKH

Wong, YF

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Obstet & Gynaecol, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

CANCER LETTERS | 2001年 / 172卷 / 01期

关键词：

p2l; p27; cervical carcinoma; human papilloma virus;

D O I：

10.1016/S0304-3835(01)00624-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：93 / 98

页数：6

共 15 条

[1] p21(WAF1) immunohistochemical expression in breast carcinoma: Correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival [J].