The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis

被引：11

作者：

Bae, Gi-Sang ^{[1
]}

Park, Kyoung-Chel ^{[2
]}

Koo, Bon Soon ^{[2
]}

Choi, Sun Bok ^{[2
]}

Jo, Il-Joo ^{[2
]}

Choi, Chang-Min ^{[3
]}

Song, Ho-Joon ^{[2
]}

Park, Sung-Joo ^{[1
,2
]}

机构：

[1] Wonkwang Univ, Coll Oriental Med, Hanbang Body Fluid Res Ctr, Iksan 570749, South Korea

[2] Wonkwang Univ, Coll Oriental Med, Dept Herbol, Iksan 570749, South Korea

[3] Wonkwang Univ, Coll Oriental Med, Dept Obstet & Gynecol, Iksan 570749, South Korea

来源：

BMB REPORTS | 2012年 / 45卷 / 07期

关键词：

Alcoholic chronic pancreatitis (ACP); Fibrosis; Nardostachys jatamansi; Pancreatic stellate cells; STELLATE CELLS; MECHANISMS; IDENTIFICATION; PROLIFERATION; APOPTOSIS; INSIGHTS; FIBROSIS; ROLES;

D O I：

10.5483/BMBRep.2012.45.7.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nardostachys jatamansi (NJ) belonging to the Valerianaceae family has been used as a remedy for gastrointestinal inflammatory diseases for decades. However, the potential for NJ to ameliorate alcoholic chronic pancreatitis (ACP) is unknown. The aim of this study was to examine the inhibitory effects of NJ on ACP. C57black/6 mice received ethanol injections intraperitoneally for 3 weeks against a background of cerulein-induced acute pancreatitis. During ACP, NJ was ad libitum administrated orally with water. After 3 weeks of treatment, the pancreas was harvested for histological examination. NJ treatment increased the pancreatic acinar cell survival (confirmed by amylase level testing) and reduced collagen deposition and pancreatic stellate cell (PSC) activation. In addition, NJ treatment reduced the activation but not death of PSC. In conclusion, our results suggest that NJ attenuated ACP through the inhibition of PSC activation. [BMB Reports 2012; 45(7): 402-407]

引用

页码：402 / 407

页数：6

共 33 条

[1]

Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines [J].