Changes in GABAB receptor immunoreactivity after recurrent seizures in rats

被引：20

作者：

Kokaia, Z ^{[1
]}

Kokaia, M ^{[1
]}

机构：

[1] Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22184 Lund, Sweden

来源：

NEUROSCIENCE LETTERS | 2001年 / 315卷 / 1-2期

关键词：

GABA(B); GABA; kindling; immunoreactivity; epilepsy; rat;

D O I：

10.1016/S0304-3940(01)02350-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABA(B) receptors play an important role in the excitability of neuronal networks and can influence seizure activity. Here we demonstrate for the first time that kindling, an animal model for human temporal lobe epilepsy, leads to both early and delayed changes of GABA(B) receptor immunoreactivity in hippocampal and cortical areas. We propose that the altered GABA(B) receptor levels might be a compensatory mechanism to reduce excitability induced by recurrent kindled seizures, or alternatively, may promote the development of kindled epilepsy. (C) 2001 Published by Elsevier Science Ireland Ltd.

引用

页码：85 / 88

页数：4

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